Comparative Study of the Lipid and Lipoprotein Profile of Overweight Consumers Versus Non-consumers of Palm Oil at the National Institute of Public Health, Côte d’Ivoire
Cisse-Camara Massara,
Monde Aké Absalome,
Ahui-Bitty Louise Berthe,
Aké Aké Alexandre,
Abodo Jacko Rhedoor,
Kambou Philipe,
Ekou Kokora Franck,
Ake-Tano Odile,
Tiahou George
Issue:
Volume 9, Issue 4, December 2021
Pages:
90-97
Received:
25 August 2021
Accepted:
14 September 2021
Published:
29 September 2021
Abstract: Palm oil is often not recommended to overweight patients, on the pretext that it provides saturated fat and cardiovascular diseases. This work studied variations in lipid and lipoprotein parameters in overweight consumers versus non-consumers of palm oil who came for visits at the nutrition department of the National Institute of Public Health of Adjamé in Abidjan, Côte d’Ivoire. We included 328 overweight subjects, including 227 palm oil consumers and 101 non-consumers, in a three-month descriptive and analytical cross-sectional, prospective study. The lipid parameters analysed by enzymatic technique were total cholesterol, triglycerides, HDL and LDL cholesterol. The atherogenicity index was also determined. The comparison of proportions was made by the chi square-test (5%). Moderate obesity accounted for 41.6%, overweight 31.2%. Among the patients, 89% consumed palm oil, and 11% did not. In palm oil consumers, 64.2% had normal cholesterol, while 16.1% had hypercholesterolemia. Among non-consumers, 75% had normal cholesterol compared to 25% hypercholesterolemia. The difference was not significant in both groups. Serum triglycerides, HDL, LDL cholesterols, and atherogenicity index varied in the same range as total cholesterol, with no significant difference observable, whatever the form of palm oil consumed. The non-significative variation of lipid and lipoprotein parameters in palm oil consumers and non-consumers, showed that normal consumption of palm oil has no significant effect on weight gain. This consumption is beneficial because of the presence of antioxidants in palm oil, which gives it its health and nutritional benefits.
Abstract: Palm oil is often not recommended to overweight patients, on the pretext that it provides saturated fat and cardiovascular diseases. This work studied variations in lipid and lipoprotein parameters in overweight consumers versus non-consumers of palm oil who came for visits at the nutrition department of the National Institute of Public Health of A...
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Design, Synthesis and Antibacterial Activities of Triazole-Pyrimidine Derivatives as SecA Inhibitors
Fanté Bamba,
Camara Tchambaga Etienne,
Coulibali Sioménan,
Akpa Sagne Jacques,
Coulibaly Souleymane,
Adjou Ané
Issue:
Volume 9, Issue 4, December 2021
Pages:
98-105
Received:
26 October 2021
Accepted:
12 November 2021
Published:
23 November 2021
Abstract: Background: To highlight the magnitude of the important challenge now facing scientists, drug resistance needs exploration of novel antimicrobial agents. The identification of new and vital target in bacteria and then designing their inhibitors can be explored. Thus, targeting SecA, a central component of the bacterial general secretion system, is a promising strategy for the development of novel antimicrobials. Objective: To evaluate new compounds as SecA inhibitors synthesized by structural modification of bistriazole SCA-21. Method: A new compounds were synthesized and evaluated for antibacterial activity against Escherichia coli NR698 (E. coli a leaky mutant), Staphylococcus aureus (S. aureus) and Bacillus anthracis (B. anthracis). Results: Some novel triazole-pyrimidine derivatives by structural modification of known SecA inhibitor SCA 21 were synthesized and their structures were confirmed by 1H NMR, 13C NMR and Mass spectral analysis. The synthesized compound showed antimicrobial activity against E. coli NR698 (a leaky mutant), S. aureus and B. anthracis Sterne. Conclusion: Five novel triazole-pyrimidine derivatives were designed, synthesized and evaluated as SecA inhibitors. At the end of this study, compound SCA 259 with azide pentyl group was found as the most potent inhibitor. It expressed better inhibitory activity against SecA ATPase than else known inhibitor SCA 21.
Abstract: Background: To highlight the magnitude of the important challenge now facing scientists, drug resistance needs exploration of novel antimicrobial agents. The identification of new and vital target in bacteria and then designing their inhibitors can be explored. Thus, targeting SecA, a central component of the bacterial general secretion system, is ...
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