Advances in Biochemistry

Volume 6, Issue 3, June 2018

  • Polymorphism of the Beta Gene in Homozygous Sickle Cell Patients in Senegal and Its Influence on the Main Complications of the Disease

    Dominique Doupa, Moustapha Djité, Pape Matar Kandji, Demba Makalou, Sira Thiam, Ousseynou Boye, Fatimetou Veten, Aminata Lam, Marie Pierre Diouf, Arame Ndiaye, Blaise Felix Faye, Souleymane Thiam, Abdourahmane Samba, Fatou Diallo, Sidy Mohamed Seck, Ahmed Ould Houmeida, Papa Madieye Gueye, Ibrahima Diagne, Saliou Diop

    Issue: Volume 6, Issue 3, June 2018
    Pages: 19-25
    Received: 3 August 2018
    Accepted: 1 September 2018
    Published: 21 September 2018
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    Abstract: Sickle cell disease has a great variability of clinical and biological expression that depends on modulatory and environmental genetic factors. This variability in clinical and biological expression encourages us to look for predictors of severity. Hemoglobin F and its genetic determinants are influencing prognostic factors. The objectives of this ... Show More