Volume 7, Issue 1, March 2019, Page: 1-4
Effects of Aframomun Chrysanthum Seed Aqueous Extract Against Acetaminophen-induced Liver Toxicity in Rats
Nwachoko Ndidi, Department of Biochemistry, Rivers State University, Nkpolu-Oroworukwo, Port Harcourt, Nigeria
Essien Eka Bassey, Department of Biochemistry, University of Port Harcourt, Choba, Nigeria
Ayalogu Edward Obiozo, Department of Medical Biochemistry, Rivers State University, Nkpolu-Oroworukwo, Port Harcourt, Nigeria
Received: Apr. 11, 2019;       Accepted: May 23, 2019;       Published: Jun. 5, 2019
DOI: 10.11648/j.ab.20190701.11      View  60      Downloads  36
Abstract
Plants and their components are the only source of most drugs which comprise of distinct groups such as antispasmodics, emetics, anticancer and antimicrobials. Plants capable of improving health conditions and treating diseases have been identified and used since human existence. A wide variety of compound synthesized from plants participate in biological roles such as defense against predators. This study examined the protective effect of Aframomunchrysanthum seed aqueous extract against acetaminophen-induced liver toxicity in rats. A suspension of 750 mg/kg acetaminophen was administered once every 72 hours to induce toxicity in the rats. This was followed by oral administration of the plant extract (500, 1000 and 2000 mg/kg) body weight and 100 mg/kg of silymarine. For ten days. Eighteen hours after the last dosage, blood sample was collected for biochemical analysis. The result showed significant (p < 0.05) increase in the activities of aspartate aminotransferase (AST), alanine aminotransferase (ALT) and alkaline phosphatase (ALP) as well as the concentrations of albumin (ALB) and total bilirubin (T. B) levels in rats administered with acetaminophen only. The levels of these parameters were significantly (p < 0.05) decreased in the groups pretreated with the extract.
Keywords
Aframomun Chrysanthum, Silymarine, Hepatoprotective
To cite this article
Nwachoko Ndidi, Essien Eka Bassey, Ayalogu Edward Obiozo, Effects of Aframomun Chrysanthum Seed Aqueous Extract Against Acetaminophen-induced Liver Toxicity in Rats, Advances in Biochemistry. Vol. 7, No. 1, 2019, pp. 1-4. doi: 10.11648/j.ab.20190701.11
Copyright
Copyright © 2019 Authors retain the copyright of this article.
This article is an open access article distributed under the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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