Interrelationship between Testosterone Level and Aldo-Keto Reductase Activity in the Blood of Different Ages Rats
Vadim Vyacheslavovich Davydov,
Evgeniya Romanovna Grabovetskaya
Issue:
Volume 2, Issue 3, June 2014
Pages:
40-44
Received:
4 June 2014
Accepted:
22 June 2014
Published:
30 June 2014
Abstract: Aldo-keto reductases play an important role in cell protection against oxidative stress and in the modulation of resistance to the effect of stress damaging factors during ontogenesis. However, there are no clear concepts about changing of their catalytic properties in the process of individual development to date. The reason may be age-dependent changes in hormonal regulation. Still there is no information about the hormonal regulation of aldo-keto reductases. Taking this into account, the present study investigated the effect of testosterone on aldo-keto reductase activity of the blood of the rats of different ages. It has been found that an increased level of testosterone in the blood of rats from 1.5 to 26 months of age was accompanied by an increased aldo-keto reductase activity and the modulation in the structure of isozymes spectrum of aldo-keto reductases. Intramuscular injections of testosterone to pubertal and adult rats increased aldo-keto reductase activity of the blood, which did not occur in immature and aged animals. The obtained data suggest that testosterone is involved in the regulation of the synthesis of individual aldo-keto reductase isozymes.
Abstract: Aldo-keto reductases play an important role in cell protection against oxidative stress and in the modulation of resistance to the effect of stress damaging factors during ontogenesis. However, there are no clear concepts about changing of their catalytic properties in the process of individual development to date. The reason may be age-dependent c...
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Effect of Dry Garlic Powder on Plasma Lipid Profile and Enzyme Activities in Some Tissues of Hypercholesterolemic Rats
Issue:
Volume 2, Issue 3, June 2014
Pages:
45-49
Received:
3 May 2013
Accepted:
27 June 2014
Published:
20 July 2014
Abstract: The effect of garlic powder at 5% and 10% level on plasma lipid profile was investigated in hypercholesterolemic rats. Male albino rats were fed a diet containing 20% fat and 1% cholesterol for two weeks to provoke hypercholesterolemia. The hypercholesterolemic rats were divided into three groups B, C and D. Group A rats were fed with normal diet, Group B were maintained on the hyper diet, Group C were fed hyper diet +5% garlic powder, Group D were fed hyper diet with +10% garlic powder. They were maintained on this diet for four weeks. Results showed that the plasma total cholesterol and LDL-C was significantly reduced in the treated groups (C and D) compared to the hypercholesterolemic control (Group B), while the HDL-C was significantly increased (P<0.05). Also plasma enzyme activities of Aspartate and Alanine Aminotransferases (AST. ALT) and Alkaline Phosphatase (ALP) showed a slight decrease in the treated rats. It is concluded that consumption of dry garlic powder at the level used in this study could be beneficial on the plasma lipid profile in hypercholesterolemia.
Abstract: The effect of garlic powder at 5% and 10% level on plasma lipid profile was investigated in hypercholesterolemic rats. Male albino rats were fed a diet containing 20% fat and 1% cholesterol for two weeks to provoke hypercholesterolemia. The hypercholesterolemic rats were divided into three groups B, C and D. Group A rats were fed with normal diet, ...
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